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Each treatment was done in triplicate, stirred for 1 h, and then allowed to settle
In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019
PPAR Res 2012:107434
Interestingly, this anti-inflammatory effect in the muscle and tendon healing, and myotendinous junction recovery [18,19,20,21,22], is along with BPC 157 anti-inflammatory effect in other models [14], counteracted adjuvant arthritis [92], capsaicin-toxicity [93], and goes with counteraction of the NSAIDs side effects [14]
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
