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12 In addition, Asp can promote the activation of hypoxia-inducible factor HIF-1 and inflammasome in M1 macrophages and increase the production of Asn and other metabolites

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Overall, constitutive autophagy maintains cardiomyocyte size, architecture, and basal performance in the healthy heart, whereas in failing myocardium, enhanced autophagy functions predominantly as a compensatory survival mechanism

Faraj S, Kemp EH, Gawkrodger DJ