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ISAMAR: multicenter phase II trial of isatuximab (ISA) with/without lenalidomide (LEN) in high risk smoldering multiple myeloma (HRSMM)

Pheomelanin is lighter in color and can contribute to a brighter skin tone

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Aim for 68 glasses of fluid daily (more during exercise or hot weather), as Wegovy can cause dehydration through gastrointestinal effects whilst creatine requires proper hydration for safety and efficacy

The dosage is gradually increased over a period of 4-5 months to reduce gastrointestinal side effects