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10.1155/2022/1767421 483 WuM.ChengY.ZhangR.HanW.JiangH.BiC.et al

Taken together, glutathione is not fully effective when taken orally, so if you want to take it orally, it is recommended to take it sublingually for better absorption

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Handling and Stability Risks Improper handling exposure to light, heat, repeated freeze-thaw cycles, or strongly alkaline conditions can degrade the peptide or disrupt copper coordination, producing experimental variability that is sometimes mistaken for biological inconsistency

[1] [2] Published laboratory studies examined its structure, receptor activity, and effects in rats and monkeys