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Mechanistically, PBP inhibits myeloperoxidase (MPO) activity, reduces neutrophil infiltration, lowers cyclooxygenase-2 (COX-2) expression, and significantly decreases serum levels of tumor necrosis factor (TNF)- and interleukin (IL)-6

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(2020) suggested that TMAO levels of 5.1 mol/L as a cut-off value for prognosis of many key unfavorable clinical events in patients with coronary heart disease