Ribosomal protein S6 kinase B1 ( RPS6KB1 ), BRCA1 DNA repair associated ( BRCA1 ), cyclin dependent kinase 1 ( CDK1 ), ribosomal protein S3 ( RPS3 ), peroxisome proliferator-activated receptor gamma coactivator 1-alpha ( PPARGC1A/PGC-1 ), acyl-CoA synthetase long chain family member 1 ( ACSL1 ), NADH:ubiquinone oxidoreductase subunit AB1 ( NDUFAB1 ), NADH:ubiquinone oxidoreductase subunit A9 ( NDUFA9 ), ATP synthase beta chain, mitochondrial ( ATP5B ), and protein kinase AMP-activated non-catalytic subunit gamma 2 ( PRKAG2 ) were suggested to be candidate genes that may affect IMF deposition [55]
Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade
Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) is a central regulator of the cellular defense line against toxic and oxidative insults
The hepatotoxicity of APAP rests predominantly with the highly toxic and reactive compound NAPQI, which forms covalent bonds with sulfhydryl groups on cysteine and lysine molecules within the mitochondria of hepatocytes and which spontaneously reacts with GSH and binds to hepatic proteins.8,11 The protein adducts formed, specifically those of mitochondrial protein adducts, lead to oxidative injury and hepatocellular necrosis
Notably, for most peptides the ratio of intensities in in-cell LiP-MS to lysate LiP-MS was close to 1 (Fig
