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NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)

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Some of the serious side effects of Vitamin B12 include serous allergic reaction, narrowing or blocking of blood vessels, thrombocytosis (a disorder where your body produces too many platelets), low potassium levels in body, pulmonary edema (a condition where there is excess fluid in the lungs) and congestive heart failure