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Because it is tied to insulin-like growth factor activity, it may affect blood sugar, tissue growth signaling, water retention, swelling, and other body systems

However, these agents are associated with increased thyroid cancer risk, and the packaging for these medications in the United States has a boxed warning stating that they are contraindicated in people with a personal or family history of medullary thyroid cancer and in patients with a diagnosis of multiple endocrine neoplasia syndrome type 2

Starting at your pre-operative dose is generally safe, though some physicians recommend restarting at a lower dose and titrating upward if you experience nausea or reduced appetite during early recovery

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