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A prospective study of 40 women with PCOS in Endocrine Practice (2021) found that 6 months of spironolactone at 100 mg/day improved self-reported sleep quality scores by 22% compared with baseline, though the study was small and uncontrolled
There is mixed evidence that high-dose vitamin E supplementation (equivalent to 180 or 360 mg/day of RRR --tocopherol from synthetic vitamin E [ dl --tocopherol]) influences the risk of heart attack in high-risk individuals (patients with coronary heart disease, type 2 diabetes mellitus, or renal failure
Christensen explores fat-free mass reduction, muscle and bone considerations, and clinical risks
4C and Fig
Immune signaling becomes less precise
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