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The hospitalization rate of patients with AKI after GLP-1RA was 45.28%, while 4.23% of patients who developed AKI died

Researchers hypothesized that, while the increased thyroid hormone increased carnitine synthesis, it also accelerated mitochondrial fatty acid oxidation (similar to what was seen to happen in a hyperthyroid state), which reduced carnitine levels

Interventions affecting systemic metabolism, such as NNMT inhibition, are likely to influence the gut microbiome

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