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The qualifications include being an adult with a body mass index (BMI) of at least 30 mg/kg or higher, or a BMI of 27 mg/kg or higher, along with a minimum of one weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol

In addition, RSL3, another ferroptosis inducer, can covalently bind to selenocysteine at the active site of GPX4, thus directly inhibiting the phospholipid peroxidase activity of GPX4 [54]

Such drugs function as inhibitors, binding to the active site by mimicking the tetrahedral intermediate of its substrate, thus disabling the enzyme

[17] Some research suggests that activation of these receptors may potentially have cardioprotective effects

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