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It is advisable for patients to maintain open communication with their healthcare provider throughout the process to discuss any changes or concerns

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According to the MHRA/EMC Summary of Product Characteristics, the most common adverse effects include: Nausea very common (affects more than 1 in 10 people), often most pronounced when starting treatment or increasing the dose Vomiting very common, typically improves as the body adjusts to the medication Diarrhoea very common Abdominal pain or discomfort common (affects up to 1 in 10 people) Decreased appetite common Constipation common Dyspepsia (indigestion) common, including bloating and flatulence These gastrointestinal effects are generally most prominent during the initial weeks of treatment and often diminish over time as the body adapts

FDA Commissioner Marty Makary stated plainly that affordability and insurance access do not constitute clinical need under the law

below the threshold for effective CAR-T on non-malignant tissues may be tolerable (156)