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Studies have demonstrated that endothelial NAD+ levels decrease by 40-60% during aging, correlating with reduced nitric oxide bioavailability and impaired vasodilation

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"This could be an important step toward personalizing treatment for depression." Haroon and his team looked at 50 patients with depression not currently receiving antidepressant treatment

Rabbits were anesthetized for these measurements, using the same protocol as for wound creation