Mediation analyses showed that nausea, vomiting, and diarrhea together accounted for only up to 3.1% of total weight reduction -- the metabolic effects do the heavy lifting
Dettmer et al
If symptoms started right after initiation or dose escalation, and especially if they correlate with severe GI intolerance, your prescriber may consider whether a slower titration, a temporary pause, a dose reduction, or switching within the GLP-1/GIP class is appropriate
metabolism and energy production.*
Immediate (first 24 hours): Cold compress for 10 to 15 minutes, repeat 3 to 4 times Do not massage, rub, or apply heat Pressure with a cotton ball for 30 to 60 seconds immediately after withdrawing the needle reduces bleeding Days 2 to 3: Switch to warm compress (10 minutes, 3 to 4 times daily) Warmth promotes reabsorption of trapped blood Arnica cream or gel can be applied (some evidence for faster bruise resolution, though not definitive) Days 4 to 14: Continue warm compresses if desired Allow natural resolution, the bruise will transition through purple, blue, green, and yellow before fading Vitamin K cream may help speed resolution (limited evidence) If you bruise frequently with injections, review your technique
