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Importantly, these changes in mitochondrial mass are not related to engagement of apoptosis: inhibition of caspase activity using zVAD-fmk did not prevent increases in mitochondrial abundance per cell (Extended Data Fig

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8 Limitations, challenges and prospects Numerous studies in the literature were focused on the anti-cancer role of bromelain, highlighting its importance in cell processes such as apoptosis and necrosis (95)

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[1] Adverse effects [edit] Safety and dosing trials showed that the incidence of adverse events in orforglipron-treated participants was 6289%, mostly from gastrointestinal discomfort (4470% with orforglipron, 18% with placebo)

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