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Superposition of the third trajectory middle stage with the previous active GLP-1R structure (PDB: 5VAI) revealed the apo-state GLP-1R may adopt a similar extended ECD conformation as in the GLP-1-bound structure (Supplementary Fig

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While glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide and tirzepatide (a dual GIP/GLP-1 agonist) have revolutionized care, the pipeline is advancing toward novel mechanisms offering potential for enhanced efficacy, tolerability, and convenience

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