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Thus, quantitative associations of NM with cell degeneration are complicated, and in some conditions increased NM may only be an indicator of toxic factors against which it tries to protect

albicans were co-infected, a thicker, denser biofilm with stronger tolerance to harmful stresses was formed on root canal dentin and glass slides, which can increase bone resorption of osteoclasts, inhibit the bone formation of osteoblasts, upregulate inflammatory cytokines such as IL-6 and TNF-, and ultimately increase the severity of dental pulp diseases

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The representative studies included in this review are summarized in Table 1 , whereas the principal mechanistic features of mitochondriaorganelle interactions are integrated in Table 2

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