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Mutations in AR receptor, AR overexpression, intracrine production, contorted expression of enzymes and cofactors of AR, autonomous activation of AR signaling by cytokines in the absence of androgen ligands, and the presence of multiple splice variants of AR are the main causative agents responsible for the therapeutic failure [12, 13]
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2 For a 505(b)(2) sponsor, these new indications represent a value continuum where they can repurpose an established molecule for a specialized population with much lower risk
Eat smaller, more frequent meals rather than three large meals dailythis approach works with the medication's effect on gastric emptying rather than against it
They achieve this by transferring bioactive lipids that modify sperm membrane fluidity and by delivering regulatory molecules that modulate calcium signaling pathways
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