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These patients were excluded from this cohort due to the unavailability of similar data for the other participants, to reduce coverability in the metabolomic analyses

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Gepants Officially named calcitonin gene-related peptide (CGRP) receptor antagonists, gepants were developed specifically to treat migraine and include the oral medicines ubrogepant (Ubrelvy) and rimegepant (Nurtec ODT) and the nasal spray zavegepant (Zavzpret)

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Women carrying certain variants may experience more pronounced weight regain during pregnancy or faster weight loss postpartum, patterns that affect treatment planning across the reproductive lifecycle