Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial
This parenteral preparation is unlikely to pose a threat of sodium chloride or fluid overload except possibly in neonates and very small infants
Moreover, theres the risk of allergic reactions, and in some cases, complications such as nerve damage could arise if treatment is delayed or not managed correctly
Category 1 is the agency does not generally intend to take action. Category 2 is significant safety risks
Supporting this finding, acute hypogonadism induced by GnRH agonist therapy in healthy men did not result in blunting of the GH response to dynamic stimulation, although basal GH secretion was marginally reduced (Veldhuis et al., 2009)