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Beyond just fixing the deficiency, its essential to understand why it happened

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JAMA J Am Med Assoc

CD4 + CD25 + Foxp3 + Tregs cell dysfunction is common in autoimmune diseases (199), and it may be converted into pathogenic Th17 cells after repeated amplification (200)

doi: 10.1016/j.ctrv.2020.102032 80 PhamTVBoichardAGoodmanARivierePYeernaHTamayoPet al