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Rapid weight loss or changes in blood flow and nerve sensitivity can increase the risk of complications like ulcers or infections

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Infection, injury, and inflammation stimulate macrophage iron uptake and storage, thereby facilitating the induction of ferroptosis

FDA approval : Approved for weight management in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related condition

There is currently no confirmed causal link between retatrutide and joint pain, as the drug remains unlicensed and Phase 3 trial data are still being collected