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The dose of ibuprofen given to mice would be approximately equivalent to a human taking 486 mg/day as previously described 27

Comprehensive reviews demonstrate that dietary patterns influence mitochondrial membrane composition, electron transport efficiency, and susceptibility to oxidative injury, reinforcing nutrition as a primary determinant of mitochondrial redox tone rather than a passive modifier (25-26)

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Rats administered with SM markedly increased GSH levels in liver, serum, testis and spleen, however, kidney and heart were not affected by SM treatment

So far, various studies in other populations have explored the association between this variant and obesity risk [39,42,84,85]