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In fact, ROS induce the three major components critical for the opening of the PTPs, the voltage-dependent anion-selective channel (VDAC), adenine nucleotide translocase (ANT) and cyclophilin D, via the oxidation of specific cysteines in their active sites 81,82

Yerrington prior to treatment

The binding of the SARS-CoV-2 spike glycoprotein with ACE2, which triggers the virus-mediated cellular uptake, can also cause a burst of inflammatory cytokine release (a cytokine storm) partially because of the decreased availability of functional ACE2

Membrane-anchored serine proteases in vertebrate cell and developmental biology

Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 GPX1 expression was absent in the cochlear SGNs of gpx1 / mice