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One of the most striking finding was the significant reduction in body weight, which was clearly dose-dependent

The overall level of evidence for the articles assessed is low and much of the practice management recommendations are only based on expert opinion

The SURMOUNT-1 clinical trial, published in the New England Journal of Medicine, demonstrated average body weight reductions of up to 20.9 percent over 72 weeks among participants taking Tirzepatide

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Once inside cells, it inhibits NF-B activation and reduces pro-inflammatory cytokine production