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Expanding the chemistry of dihaloacetamides as tunable electrophiles for reversible covalent targeting of cysteines

Also, these self-injectable pens have become increasingly popular due to their simplicity, reliability, and ability to be self-administered directly by a patient without the aid of a physician

a ) the carboxyl group makes electrostatic interactions with Arg439 and Arg929 of IRAP and b ) phenyl ring of the phenylacetic acid group makes pi-stacking interactions with Tyr961