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Discovery of a potent, selective, and orally bioavailable c-met inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

Cell (1992) 70(2):31322.10.1016/0092-8674(92)90105-L 58 NosakaTvan DeursenJMTrippRAThierfelderWEWitthuhnBAMcMickleAPet alDefective lymphoid development in mice lacking Jak3

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Supplementation also reduced oxidative stress and doubled the effectiveness of Natural Killer immune cells

Sequences were aligned to the rat genome (mRatBN7.2), and read quantification was performed using the HISAT2 and featureCounts functions, respectively