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Prolonged or high-dose use of BPC-157 may carry a theoretical risk of vascular proliferation in undesired tissues, particularly in individuals with cancer or pre-existing vascular disease. Perovic, D
Preclinical protocols vary widely in dose, species, and tissue target
However, in one year-long phase 3 trial involving 2,000 severely obese patients, disappointing results were seen in the axokine-treated group [75]
Proposed mechanisms of AOD-9604: Stimulates lipolysis (fat breakdown) Increases fat oxidation Promotes mobilization of stored fat Influences lipid metabolism Importantly, AOD-9604 does not appear to significantly increase growth hormone levels, IGF-1 levels, water retention, or organ growth
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