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Based on Phase 2 trial data, the most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which are typically mild to moderate and most pronounced during dose escalation

Originally developed to treat type 2 diabetes (T2D), these drugs have since delivered major advances in managing obesity and cardiovascular risk reduction

Glucagon-like peptide-1 in the rat brain: distribution of expression and functional implication

But are they really necessary and, more importantly, do they work as advertised

Clinical trials have shown that semaglutide and liraglutide are generally well tolerated, with gastrointestinal disorders being the most commonly reported AEs, including nausea, diarrhea, vomiting, and constipation, leading to dose reduction or temporary treatment interruption in 12.5% of study participants [40,41,42]