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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications

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10.1016/j.jcis.2020.04.065 Eriksson M, Claesson P, Jarn M, Tuominen M, Wallqvist V, Schoelkopf J, Gane P and Swerin A

Homeostatic eating, driven by energy needs, diminishes as satiety signals strengthen