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The cyclical dosing structure researchers use escalating within a defined window, followed by a rest period reflects an understanding of the peptide as a signaling molecule rather than a substance that accumulates and produces dose-dependent effects the way a drug typically does

It occurs among the elderly, women who have undergone menopause, or given birth

Supplementary Material Funding: This study was funded by a research grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK138036)

Exploratory analyses We tested our moderation hypotheses by mean-centering each proposed moderator and testing the interaction between the moderator and study condition in a multiple linear regression model