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Most providers require at least three weeks at each dose before increasing, but some flexibility exists based on individual tolerance

If a patient needs sustained, multi-year weight management, a 12-week tool cannot deliver it on its own and if a patient needs a brief, affordable kickstart, an open-ended chronic therapy may be more than the situation requires

Method Umbrella review methods This umbrella review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is prospectively registered with PROSPERO (CRD42024585231)

Research vials should always be stored in opaque containers or secondary packaging that blocks light

But research about their use and side effects is still taking shape