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Serious adverse events are less common but documented: pancreatitis, gallbladder disease, hypoglycemia (particularly in patients on concomitant diabetes medications), and a boxed warning regarding medullary thyroid carcinoma risk in rodent studies - a finding whose clinical significance in humans at therapeutic doses remains under study

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One small randomized controlled trial found that exenatide significantly lowered ICP within hours

This exceeded tirzepatide benchmarks in a shorter study duration with a smaller sample size, generating enormous interest in the Phase 3 program that followed