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Rare but serious gastrointestinal complications have been reported in post-marketing surveillance, including: Acute pancreatitis : If suspected, the GLP-1 agonist should be stopped immediately and not restarted if pancreatitis is confirmed Severe gastroparesis : Rare post-marketing reports of severe delayed gastric emptying Intestinal obstruction : Very rare cases reported in post-marketing surveillance Patients should be advised to seek urgent medical help via NHS 111, A&E or 999 as appropriate if they experience severe or persistent abdominal pain, persistent vomiting, abdominal distension, inability to pass stool or gas, or bloody diarrhoea whilst taking GLP-1 agonists

Histopathological analysis confirms that tumor cell accumulation is localized within the dissolving hydrogel, while adjacent neural parenchyma remains unperturbed

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They can affect the release and activity of neurotransmitters such as dopamine and serotonin, which play a crucial role in emotional well-being, Arillotta added