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Sermorelin: previously FDA-approved as Geref, discontinued in 2008 for business reasons rather than safety

The peptide treatment mitigated bleomycin-induced transcriptional alterations in genes involved in stress response, inflammation, and fluid homeostasis, leading to a significant reduction in interstitial edema and down-regulation of proinflammatory and profibrotic factors

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Identify success criteria (50% pain reduction, specific functional milestone) guiding protocol duration and modification decisions