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Semaglutide overcomes this through two structural modifications: an alanine-to-Aib substitution at position 8 (which removes the DPP-4 cleavage site) and the attachment of a C18 fatty diacid chain via a bifunctional linker at lysine position 26

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Why Some Patients Maintain Results While Others Rebound Why do some people successfully maintain a stable body weight while others experience rapid weight gain