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Our findings indicate that metformin-thiazolidinedione combinations (metformin & rosiglitazone/pioglitazone) have the highest impact in preventing AD, primarily through AMPK, PPAR, insulin, and adipocytokine signaling pathways

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Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017

The medication slows gastric emptying, increases satiety, and improves insulin sensitivity

*Best is still relative, namely there are limited studies