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Combining the two classes amplifies GH release more than either alone

14% in placebo-treated individuals

A 2014 paper in the International Journal of Colorectal Disease reported a Phase 2 randomized controlled trial of ipamorelin for the management of postoperative ileus in bowel-resection patients, providing one of the few human-clinical-trial datasets for this class of molecule (PMID 25331030)

and (2) that making the stomach pump more effectively would inevitably lead to symptom improvement