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At the same time, we are facing an exciting multifaceted future, with several novel developments on the horizon with the potential to change the clinic setting, including the development of oral GLP-1 receptor agonists and the emerging formulations of GIP receptor agonists and dual and triple receptor agonists, which have shown clear therapeutic potential

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Figure 5 : Overlap of obesity and diabetes With Lilly and Novo Nordisk currently the only two companies with approved weight loss medications in the US and international markets, the companies generated a combined $32bn in the US market last year alone and almost another $10bn outside the US

FLAG staining was also performed and (E) hGLP-1R islets stained positive for FLAG with none detected in (D) mGlp-1r and (F) Glp-1r/ islets