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While these studies show positive effects on performance outcomes, they do have small sample sizes, and findings must be generalized with caution

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Furthermore, research on rats shows that IGF-1 increases excitatory synaptic transmission in CA1 by 40%

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Moreover, acetyl-l-carnitine is an epigenetic regulator of genes involved in analgesia such as the metabotropic glutamate 2 receptor in the presynaptic neurons and of neurotrophic factors including nerve growth factor