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For type 2 diabetes, NICE guidance (NG28) recommends GLP-1 RAs based on individual factors including comorbidities, prior treatments, and HbA1c targets

Preclinical work also points to applications in reproductive health (e.g., PCOS-related fertility improvements) and oncology, where observational studies link GLP-1 use to lower risks of obesity-related cancers

Despite the widespread clinical use and scientific interest surrounding GLP-1 RAs, only a handful of neuroimaging studies have investigated their effects on brain activity, and these studies are methodologically heterogeneous

this may be of particular concern in older patients who often experience a natural decline in renal function with age and may be more susceptible to the effects of dehydration

Engelman is clear: Not necessarily, but many of these formulations contain ingredients that are beneficial for skin health across the board and address universal needs. To be clear, Engelman gets behind the supercharged skincare ingredients in these new offerings, but believes theyre not the only players that deliver results