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Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12)

These effects are typically mild to moderate, most pronounced during dose escalation, and diminish as the body adjusts to the medication

The pivotal trials behind that class include STEP (semaglutide, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

Accounting for these ensures accurate budgeting

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