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Genetic Variations (GSTM1, GSTP1 Polymorphisms) Polymorphisms in genes encoding glutathione S-transferases (GSTs) can reduce detoxification capacity and glutathione efficiency by 20-40%

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Your healthcare provider will then increase the dose approximately every 30 days or so (e.g., to 4 mg, then 9 mg) up toward a 25 mg once-daily maintenance dose, depending on your tolerance