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Integrative Medicine: A Clinician's Journal, 13(1), p.8

Given the wide variety of symptoms and potential long term effects of untreated B12 deficiency, its important to be aware of the signs and seek medical advice if you suspect youre affected

Energy levels begin to stabilize and improve

Since it is a water-soluble vitamin and your body uses just what it needs at that time and eliminates the excess through the bodys normal waste process, it cannot build up in your system

For a researcher trying to isolate variables and observe a clear dose-response relationship in a specific joint, maximizing the local concentration is a logical step