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A wide differential diagnosis should be considered (i.e., druginduced or smokinginduced melanosis, an endocrinopathy, or a syndromic condition)

Losing weight shrinks fat cells and reduces this upward pressure, but if your skin lacks elasticity or your connective tissue structure is genetically prone to dimpling, cellulite may persist even after significant weight loss

(1) Cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in patients with heart failure

Decreases cell damage by combatting with free radicals 2