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Reporting helps build the safety evidence base for emerging medicines

You should always carefully evaluate all available information and consult Elders or another advisor further before you commit to any course of action or rely on any recommendation

Pharmacokinetic-pharmacodynamic modeling could optimize dosing regimens based on target tissue exposure and response relationships

This strategy employs multiple phases of research, beginning with an optimization phase during which components are assessed individually and in combination and decisions are made about which combination to move forward

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