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Genetic Factors in Semaglutide Sensitivity and Dosing The PlexusDx Precision Peptide Genetic Test analyzes GLP1R (rs6923761), and GIPR (rs1800437) variants that relate to GLP-1 and related signaling pathways

Upregulated gene sets included those associated with GPCR signaling, neuropeptide receptor interactions and ligand binding, cilia formation, metabolic processes, and endocrine function Supplemental Figure 5B)

Glutathione-S-transferase mu 2 ( GSTM2 ), as a member of phase II drug metabolizing enzymes (DMEs), regulates cellular antioxidant and detoxificant