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in men, those with the highest serum magnesium had a 27% less risk compared with those whose levels were lowest

FOXO4-DRI releases p53 from this inhibitory interaction, enabling activation of downstream genes involved in mitochondrial apoptosis pathways

For the quantification of these metabolites in TIF samples, 5 l samples were extracted in 45 l ice-cold extraction solvent (75% acetonitrile, 25% methanol and 0.1% formic acid) containing isotope-labelled internal standards (36 M 13 C 2 , 15 N-GSH, 0.92 M 13 C 4 , 15 N 2 -GSSG and 10 M D 4 -cystine)