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Decoding addiction in the brain Increasingly, research on the link between GLP-1 drugs and addiction offer tantalizing insights into the biology of the addicted brain, experts say, hinting at a future generation of medications designed to tackle addictions at their source

Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies

Metabolites in pentose phosphate pathway are abundant, probably due to demand for antioxidants, NADPH, gluconeogenesis and anabolic metabolism

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