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Historically, centrally acting peptides were avoided due to concerns about neuropsychiatric side effects and bloodbrain barrier delivery

Given its critical importance, vitamin B9 deficiency is associated with severe neurological complications, such as spinal cord and peripheral nerve disease, dementia, organic brain syndrome, and pyramidal tract damage (19, 21, 64)

(2023, March 21)

Notably, the BLA resubmission was accepted with priority review and the PDUFA target action date has been set for January 10, 2026

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